Dovitinib Dilactic Acid ( Dovitinib Dilactic acid | TKI258 Dilactic acid | CHIR-258, TKI258 )

产品货号. M17618 CAS No. 852433-84-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Dovitinib Dilactic Acid
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

多韦替尼二乳酸（TKI258二乳酸）是多韦替尼的二乳酸，多韦替尼是一种多靶点RTK抑制剂。
产品描述

Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
体外实验

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体内实验

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同义词

Dovitinib Dilactic acid | TKI258 Dilactic acid | CHIR-258, TKI258
通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

c-Kit| FGFR1| FGFR3| FLT3| VEGFR3/FLT4
研究领域

Cancer
适应症

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CAS Number

852433-84-2
分子量

572.59
分子式

C21H21FN6O·2C3H6O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : ≥ 30 mg/mL (52.39 mM)
SMILES

CC(C(=O)O)O.CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3
化学全称

2-Hydroxypropanoic acid compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1- piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone

1. Trudel S, et al. Blood. 2005, 105(7), 2941-2948.

计算器

产品手册

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